Laminar LAAX Pivotal IDE Study
The goal of this clinical trial is to compare the Laminar Left Atrial Appendage Closure
System to commercially available left atrial appendage closure devices. This procedure is for
patients with non-valvular atrial fibrillation who are at increased risk for stroke,...
Age: 18 years - 66+
Gender: All
LS-PersAFone: Pulsed Field Ablation for Long-Standing Persistent Atrial Fibrillation
This is a prospective, single-arm trial. The objective of the study is to determine the rate of atrial arrhythmia recurrence after pulmonary vein isolation (PVI) plus posterior wall isolation (PWI) using the Farawave PFA catheter in patients with longstanding persistent...
Age: 18 years - 66+
Gender: All
Versatility of a Circular Multielectrode Catheter in the Individualized Recognition & Treatment of Atrial Fibrillation and Related Arrhythmias Using Pulsed Field Energy
The purpose of this pragmatic study is to evaluate the safety, performance and effectiveness
of the VARIPULSE catheter technology used in combination with the TRUPULSE™ Generator, and
the compatible EAM system (Carto 3D) to treat patients with atrial fibrillation an...
Age: 18 years - 66+
Gender: All
ULTRA-HFIB-Redo: Ultrasound-based Renal Sympathetic Denervation vs Control in Redo Ablation Patients
This is a Prospective, controlled, single-blind, randomized (2:1, Intervention:Control) clinical trial. The purpose of the study is to determine the role of adjunctive renal sympathetic denervation in the prevention of Atrial Fibrillation (AF) recurrence in patients wit...
Age: 18 years - 66+
Gender: All
RESOLVE-AF: Clinical Evaluation of the Ablacath™ Mapping Catheter and Ablamap® System Utilizing Electrographic Flow (EGF) Mapping to Resolve Extra-PV Sources of Atrial Fibrillation and Guide Ablation Therapy.
Demonstrate the safety and effectiveness of the Ablacath™ Mapping Catheter and Ablamap®
System in patients with all types of atrial fibrillation (AF) including paroxysmal or
persistent or long-standing persistent, undergoing and De Novo or Redo procedures.
Pheno...
Age: 18 - 80 years
Gender: All
Amplatzer Amulet LAAO vs. NOAC
The objective of this trial is to evaluate the safety and effectiveness of the Amulet LAA
occluder compared to NOAC therapy in patients with non-valvular AF at increased risk for
ischemic stroke and who are recommended for long-term NOAC therapy.
The clinical in...
Age: 18 years - 66+
Gender: All
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG
The primary objective of this study is to evaluate the effectiveness (prevention of
thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to
background antiplatelet therapy in patients who develop new-onset post-operative atrial
f...
Age: 18 years - 66+
Gender: All
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery
Primary Aim: To determine if apixaban is superior to aspirin for prevention of the composite
outcome of any stroke (hemorrhagic or ischemic) or death from any cause in patients with
recent ICH and atrial fibrillation (AF).
Secondary Aim: To determine if apixaban...
Age: 18 years - 66+
Gender: All
TactiSense IDE Trial of TactiCath SE for Paroxysmal Atrial Fibrillation
This clinical investigation is intended to demonstrate the acute safety and effectiveness of
ablation with the TactiCath™ Contact Force Ablation Catheter, Sensor Enabled™ (TactiCath SE)
for the treatment of drug refractory recurrent symptomatic paroxysmal atrial fibri...
Age: 18 years - 66+
Gender: All
CardioFocus HeartLight Post-Approval Study
This is a post-approval study to evaluate the clinical outcomes in a cohort of participants
treated during commercial use of the HeartLight System to confirm results of the previously
conducted pivotal clinical study.
Age: 18 years - 66+
Gender: All
Assessment of the WATCHMAN™ Device in Patients Unsuitable for Oral Anticoagulation
The purpose of this study is to establish the safety and effectiveness of the WATCHMAN™ Left Atrial Appendage Closure (LAAC) Device, including the post-implant medication regimen, for subjects with non-valvular atrial fibrillation who are deemed not to be eligible...
Age: 18 years - 66+
Gender: All
AtriClip® Left Atrial Appendage Exclusion Concomitant to Structural Heart Procedures (ATLAS)
Patients without a documented history of AF but who present with a CHA2DS2- VASc of => 2 and HASBLED of => 2 and will undergo a valve or CABG (structural heart) procedure with direct visual access to the LAA will be eligible to participate based upon the inclusion...
Age: 18 years - 66+
Gender: All
Feasibility Study of a Left Atrial Appendage Closure Device in Patients With Atrial Fibrillation
The purpose of this study is to assess the safety and function of the Aegis Sierra Ligation
System in accessing and closing off the left atrial appendage (LAA) using a minimally
invasive epicardial access approach.
A minimum of 30 participants will be included in thi...
Age: 18 years - 66+
Gender: All